Dronedarone hydrochloride targets cardiolipin and phosphatidylglycerol to increase colistin susceptibility in gram-negative pathogens.

ABSTRACT: Treating multidrug-resistant (MDR) infections has become progressively dependent on limited therapeutic options, particularly polymyxins, such as colistin. This reliance has precipitated a concerning epidemiological trend: the emergence and global propagation of plasmid-mediated (mcr) as well as chromosome-mediated polymyxin resistance. Consequently, escalating resistance rates will certainly lead to diminished clinical efficacy of colistin, correlating with elevated mortality in septic patients who already face therapeutic limitations. Utilizing antimicrobial potentiators to restore the sensitivity of resistant pathogens to polymyxins represents a promising pharmacological strategy for reinvigorating the clinical utility of these agents. Here, we demonstrate that dronedarone hydroc

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12584652 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature