Deletion of the <i>hslV</i> gene alleviates the virulence and lethality of <i>Salmonella</i> Typhimurium in hosts by modulating <i>lon</i> and T3SS-1.

ABSTRACT: Salmonella Typhimurium (S. Typhimurium) is a major foodborne pathogen that utilizes flagella-mediated biofilm formation and type III secretion systems (T3SSs) to initiate infections, contributing significantly to its virulence and antibiotic resistance. Despite its serious threat to public health, effective therapeutic strategies that simultaneously target T3SS effectors and biofilm remain underdeveloped. In this study, we deleted the hslV gene in S. Typhimurium (ΔhslV) and demonstrated that the ΔhslV strain exhibited significantly impaired bacterial adhesion, invasion, and intracellular proliferation in host cells. These defects were rescued upon genetic complementation. In vivo studies further revealed that the ΔhslV strain exhibite

SUBMITTER: Lu Q 

PROVIDER: S-EPMC12584653 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature