Emergence and dissemination of <i>bla</i><sub>KPC-31</sub> and <i>bla</i><sub>PAC-2</sub> among different species of Enterobacterales in Colombia: a new challenge for the microbiological laboratories.
Ontology highlight
ABSTRACT: Ceftazidime/avibactam (CZA) is a promising treatment option for infections caused by carbapenem-resistant Enterobacterales (CRE). However, CZA resistance is increasingly reported worldwide, largely due to the emergence of KPC variants and increase of metallo-β-lactamases (MBL). This study describes the mechanisms associated with CZA resistance in circulating Enterobacterales isolates from Colombia, highlighting the challenge this represents for microbiological identification. Between 2021 and 2024, 68 CZA-resistant Enterobacterales isolates were identified by automated methods in seven Colombian cities. Resistance to CZA was subsequently confirmed by broth microdilution and E-test. Carbapenemase production was evaluated using phenotypic tests, such as the mCIM test, Carba NP, lateral flow
SUBMITTER: Castro BE
PROVIDER: S-EPMC12584661 | biostudies-literature | 2025 Nov
REPOSITORIES: biostudies-literature
ACCESS DATA
