Urine PCR testing as an effective method for early diagnosis of leptospirosis.

ABSTRACT: The role of urine PCR for leptospirosis diagnosis in the first week is controversial due to assumed limited urine excretion. This study analyzed the prescribing practices and sensitivity of blood and urine Leptospira PCR, particularly in early stages of infection. A study was conducted on adult patients diagnosed with leptospirosis in French Guiana between 2016 and 2022 by positive Leptospira PCR, or titer of Micro-Agglutination Test > 1/200, or positive IgM with no alternative diagnosis. The timing of PCR tests and their sensitivity were analyzed. A multivariate logistic regression was performed to identify the factors associated with the sensitivity and predict the probability of having a positive result. Among 188 analyzed patients, 137 (73%) and 61 (32%) underwent blood and urine PCR t

SUBMITTER: Le Turnier P 

PROVIDER: S-EPMC12584711 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature