The combinations of cefazolin with linezolid and cefazolin with clindamycin are indifferent against methicillin-susceptible <i>Staphylococcus aureus</i>.

ABSTRACT: Antimicrobial combinations resulting in synergy against Staphylococcus aureus are desirable for improving clinical efficacy in the treatment of severe infections caused by this pathogen. Despite an existing biological rationale for the combination of cefazolin and linezolid for methicillin-susceptible S. aureus (MSSA), this combination has yet to be evaluated for in vitro synergy. We employed the checkerboard and E-test methods of synergy assessment to evaluate cefazolin in combination with linezolid against 19 clinical MSSA isolates from two centers and compared the findings to cefazolin in combination with another protein synthesis inhibitor, clindamycin. Synergy was determined using the fractional inhibitory concentration index (FICI) through both the checkerboard a

SUBMITTER: Mellett M 

PROVIDER: S-EPMC12584723 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature