Pangenome analysis of <i>Lactobacillus mulieris</i> strains reveals distinct subspecies clusters with defined ecological adaptations.

ABSTRACT: Lactobacillus mulieris is a recently described species, reportedly isolated from human urine, vagina, and gut. Previous genomic studies of L. mulieris highlighted significant genetic diversity among its strains. To gain a deeper understanding of this genomic diversity, we conducted a comprehensive genomic comparison of 70 L. mulieris strains from diverse sources. Phylogenomic and genome relatedness analysis identified three distinct clades, each representing a potential subspecies cluster. Pangenome analysis revealed distinct gene clusters shaping the functional characteristics and unique ecological adaptations of each clade. Clade 1 demonstrated a generalist lifestyle, with strains isolated from diverse sources and enriched in serine/threonine protein kinases,

SUBMITTER: Montecillo JAV 

PROVIDER: S-EPMC12584728 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature