<i>Caenorhabditis elegans</i> AWC neuron-mediated chemosensation negatively modulates dormancy during <i>Salmonella fepB</i> mutant infection.

ABSTRACT: In our earlier work, we demonstrated that continuous 8-day exposure of Caenorhabditis elegans to a Salmonella enterica serovar Typhimurium fepB mutant strain negatively regulates dauer larva development in the second generation of the population. Our current study aims to understand how specific chemosensory neurons in C. elegans recognize the ∆fepB Salmonella Typhimurium strain and undergo plasticity in response to infection. We observed the olfactory preference of C. elegans toward the pathogenic wild type Salmonella (WT-STM). However, prolonged exposure showed enhanced lawn occupancy of nematodes in the ∆fepB strain with better associative learning response than the WT-STM counterpart. We also observed upregulation of chemosensory

SUBMITTER: Mallick S 

PROVIDER: S-EPMC12584732 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature