Blood transcriptomic profiling reveals gene expression alterations in patients with SFTS-associated encephalitis.

ABSTRACT: Severe fever with thrombocytopenia syndrome (SFTS), a life-threatening tick-borne zoonosis caused by severe fever with thrombocytopenia syndrome virus (SFTSV), frequently leads to fatal encephalitis characterized by consciousness disorders and seizures. The molecular mechanisms governing SFTSV neuroinvasion and host-driven neural injury remain largely elusive. To explore the mechanisms of SFTS-induced brain damage, we analyzed clinical laboratory parameters and conducted transcriptomic analyses of peripheral blood mononuclear cells from five SFTS patients with encephalitis and five non-encephalitis patients admitted to Nanjing Drum Tower Hospital during the same period. Our findings indicate that central nervous system manifestations in SFTSV infection are associated with altered expressio

SUBMITTER: Wu D 

PROVIDER: S-EPMC12584758 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature