Gut microbiome enterotypes drive divergent lactation performance in dairy goats through host-microbe metabolic cross-talk.

ABSTRACT: The gut microbiome plays a pivotal role in modulating nutrient metabolism and lactation efficiency in ruminants, yet its functional stratification into enterotypes and implications for dairy goats remain unexplored. Here, we identified two distinct gut microbiome enterotypes in 134 lactating dairy goats: TR-cluster (n = 43) was enriched in Turicibacter, Romboutsia, and Clostridium sensu stricto 1, while CO-cluster (n = 91) exhibited higher abundance of Christensenellaceae R-7 and Oscillospiraceae UCG-005. Goats in the TR-cluster exhibited higher milk yield, fat-corrected milk yield, and milk fat yield, along with increased concentrations of total volatile fatty acids (VFA), including acetate, propionate, and butyrate in the gut, as well as e

SUBMITTER: Wang D 

PROVIDER: S-EPMC12584760 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature