Global genomic survey of <i>Salmonella</i> Kentucky: discovery of a chromosomeborne <i>bla</i>_NDM-5 and the emergence of ST314, an MDR clone mediated by the IncR plasmid.

ABSTRACT: Antimicrobial resistance (AMR) in Salmonella enterica serotype Kentucky (S. Kentucky) is a global challenge, with increasing resistance to cephalosporins, ciprofloxacin, and carbapenems significantly limiting treatment strategies, yet its worldwide dissemination patterns and AMR profiles remain unclear. Therefore, this study monitored the current trends in global spatiotemporal distribution and AMR of 9,557 S. Kentucky from 47 countries through large-scale genome-based molecular epidemiology. We revealed that S. Kentucky demonstrated a broad geographic distribution, with ST314 emerging as a novel epidemic sequence type, particularly in China. Additionally, we found chicken supply chain represents the main source for the transmission of S. Kentucky ST314 t

SUBMITTER: Chen K 

PROVIDER: S-EPMC12584844 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature