Myomaker and Myomixer are required for craniofacial myoblast fusion in zebrafish.

ABSTRACT:

Background

Craniofacial and trunk skeletal muscles are derived from different progenitor populations during development. Trunk skeletal muscles contain mostly multinucleated myofibers that are formed through myoblast fusion. However, myoblast fusion in craniofacial muscles and its molecular regulation are not well understood. Recent studies revealed that genetic mutations in MYOMAKER and MYOMIXER fusogens in humans cause Carey-Fineman-Ziter Syndrome (CFZS), characterized by facial weakness and lower jaw deformity.

Results

Previous studies in zebrafish revealed that knockout of myomaker and myomixer resulted in deformed craniofacial formation. To establish the causal connection between loss of fusogen function and craniofacial deformities, we characterized myoblast fusion in

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12584863 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature