Population structure of <i>Mycobacterium avium</i> subsp. <i>hominissuis</i> provides new insights into genomic evolution.

ABSTRACT: Mycobacterium avium subsp. hominissuis (MAH) is a clinically important species of non-tuberculous mycobacteria that causes infections in a variety of hosts. This opportunistic pathogen is widespread in the environment, including natural and engineered water systems across the globe. To examine the current genetic diversity of this organism, we analysed 702 MAH genomes isolated from humans, pigs and environmental sources across six countries and three continents. Through Bayesian population structure analysis, we identified ten distinct global lineages, including seven previously described and three new ones. Several lineages exhibited regional clustering, including sequence cluster 6 (SC6) in Germany and SC8 in both the USA and Germany. Further analysis identified recombinati

SUBMITTER: Olawoye IB 

PROVIDER: S-EPMC12584985 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature