Environmental noise-induced changes to the IC-SNc circuit promotes motor deficits and neuronal vulnerability in a mouse model of Parkinson's Disease.

ABSTRACT: Emerging clinical evidence suggests a link between environmental noise and the severity of Parkinson's disease (PD). However, the effects of high-decibel noise exposure on PD and its underlying mechanisms remain unclear. In this study, we demonstrate that acute noise exposure induces reversible motor deficits in subacute low-dose 6-hydroxydopamine (6-OHDA) mice, a model of presymptomatic early-stage PD, while chronic noise exposure results in irreversible motor deficits and significant loss of substantia nigra compacta (SNc) dopaminergic (DA) neurons. Additionally, noise exposure activates the inferior colliculus (IC), which sends monosynaptic projections to SNcDA neurons. Optogenetic or chemogenetic bidirectional activation or inhibition of the IC-SNc circuit can mimic or reverse the 6-OH

SUBMITTER: Cui C 

PROVIDER: S-EPMC12585016 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature