Adolescent morphine exposure does not alter low-dose lipopolysaccharide (LPS)-induced sickness behavior in adult C57/BL6 mice.

ABSTRACT: Adolescent opioid use in the United States commands attention: millions of twelve- to nineteen-year-olds are exposed to opioids each year by prescription and misuse. Recent findings show that opioids bind not only to canonical opioid receptors but also interact with receptors on immune cells within both the central and peripheral nervous systems. The potential for early life opioid exposure to give rise to long-term changes in the neuroimmune system is not fully understood, particularly given the adolescent brain's high susceptibility to neuroplastic changes. The goal of this study was to investigate the hypothesis that adolescent opioid use potentiates physiological and behavioral responses to lipopolysaccharide (LPS)-induced sickness later in life. To achieve this, we treated adolescent

SUBMITTER: Davidson NV 

PROVIDER: S-EPMC12585049 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature