Recovery of the full in vivo firing range in post-lesion surviving DA SN neurons associated with Kv4.3-mediated pacemaker plasticity.

ABSTRACT: Dopamine (DA) neurons in the substantia nigra (SN) control several essential functions, including the voluntary movement, learning, and motivated behavior. Healthy DA SN neurons show diverse firing patterns in vivo, ranging from slow pacemaker-like activity (1-10 Hz) to transient high-frequency bursts (<100 Hz), interspersed with pauses that can last hundreds of milliseconds. Recent in vivo patch experiments have started to reveal the subthreshold mechanisms underlying this physiological diversity, but the impact of challenges like cell loss on the in vivo activity of adult DA SN neurons, and how these may relate to behavioral disturbances, is still largely unknown. We investigated the in vivo electrophysiological properties of surviving SN DA neurons after partial unilateral 6-OHDA lesion

SUBMITTER: Kovacheva L 

PROVIDER: S-EPMC12585177 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature