Misclassification in memory modification in <i>App^NL-G-F</i> knock-in mouse model of Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD), the leading cause of dementia, could potentially be mitigated through early detection and interventions. However, it remains challenging to assess subtle cognitive changes in the early AD continuum. Computational modeling is a promising approach to explain a generative process underlying subtle behavioral changes with a number of putative variables. Nonetheless, internal models of the patient remain underexplored in AD. Determining the states of an internal model between measurable pathological states and behavioral phenotypes would advance explanations about the generative process in earlier disease stages beyond assessing behavior alone. Previously, Gershman et al., 2017b proposed the latent cause model, which provides a normative account of memory modification

SUBMITTER: Huang ML 

PROVIDER: S-EPMC12585179 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature