Adequate Catchment Area Representation in Cancer Clinical Trials at NCI Designated Cancer Centers: The University of California Irvine Experience.

ABSTRACT:

Background

Ensuring that clinical trial enrollment reflects the demographics and disease burden of a cancer center's catchment area is essential for improving trial accrual and the generalizability of research findings. We hypothesized that aligning the clinical trial portfolio with the needs of the catchment area can enhance enrollment and access to novel therapeutics.

Methods

A retrospective cohort study was conducted at the University of California Irvine Chao Family Comprehensive Cancer Center (CFCCC), an National Cancer Institute-designated cancer center serving Orange County (OC), California-the 6th largest populous county in the United States. Clinical trial enrollment data from 2015 to 2023 were analyzed using the CFCCC clinical research database. Patient demographic

SUBMITTER: Lee F 

PROVIDER: S-EPMC12585292 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature