Stepwise connectivity of the entorhinal cortex along connectomic gradients in Alzheimer's disease.

ABSTRACT: The entorhinal cortex is one of the earliest sites of tau tangle deposition in Alzheimer's disease. Existing connectome studies focus on tau propagation along direct, first-order connections between brain regions, overlooking multi-step, higher-order connections that contribute to the spread of pathology in the brain. We propose a novel quantitative integration of graph theory-based stepwise connectivity with low-dimensional connectome gradient space, which reflects the brain's hierarchical organization. This allows us to elucidate multi-step connectivity between the entorhinal cortex (seed region) and the rest of the brain along the major axes of functional and structural brain organization. In this study, we included 213 participants from the Translational Biomarkers in Aging and Dementi

SUBMITTER: Tan JXM 

PROVIDER: S-EPMC12585350 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature