Chromatin context shapes DNA damage formation and nucleotide excision repair dynamics in Caenorhabditis elegans.

ABSTRACT: DNA damage formation and repair are influenced by the genomic landscape, yet how chromatin and transcriptional activity shape these processes at a whole-organism scale remains incompletely understood. Using Caenorhabditis elegans, a widely used model organism to study DNA repair and related processes, we present comprehensive, time-course maps of ultraviolet-induced DNA damage and excision repair, revealing how chromatin context and transcription dictate the spatiotemporal patterns of damage and repair. Of the two repair pathways-global repair and transcription-coupled repair-global repair predominates, removing the majority of the lesions; and notably, (6-4) photoproducts are removed by transcription-coupled repair at an extent comparable to cyclobutane pyrimidine dimers, a feature not pr

SUBMITTER: Kose C 

PROVIDER: S-EPMC12585911 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature