Intrapleural Administration of Hypotonic Cisplatin for Patients With Malignant Pleural Effusions and Non-Expandable Lungs.

ABSTRACT:

Background/objectives

Thoracostomy and pleurodesis are the mainstay of management for malignant pleural effusions (MPEs). However, pleurodesis may not be effective for patients with MPEs and non-expandable lungs. Intrapleural chemotherapeutic agents such as hypotonic cisplatin are reportedly useful for treating MPEs with expandable lungs; however, their efficacy in patients with non-expandable lungs remains unclear. We aimed to analyze the efficacy and safety of intrapleural administration of hypotonic cisplatin in patients with MPEs and non-expandable lungs.

Methods

We retrospectively analyzed patients with MPEs of thoracic malignancies who were administered intrapleural hypotonic cisplatin. We investigated the changes in drained fluid volume, radiological outcomes at 4 wee

SUBMITTER: Mori W 

PROVIDER: S-EPMC12585921 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature