Longitudinal tractography of the mouse corpus callosum reveals topographical order and differences due to sex and aging.

ABSTRACT: The corpus callosum (CC) is the major tract connecting the two hemispheres in placental mammals and diffusion-weighted (DWI) MRI has revealed the meso/macroscopic organization of human CC and its organization of connectivity with the cortex. Here, we applied longitudinal DWI probabilistic tractography to study the CC fibers of mice across the adult lifespan. Our results reveal that connections of eight cortical areas can be delineated within the CC. The mouse CC organization aligns with the human topographical organization with frontal areas occupying the genus and parieto-occipital the posterior splenium region. A further regional analysis of passage fields showed stable field sizes in many of the studied areas over time. In contrast, several areas of the mouse default mode network and mo

SUBMITTER: Ozalay O 

PROVIDER: S-EPMC12586224 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature