PLOD1 promotes gastric cancer metastasis and immune escape by mediating extracellular matrix remodeling.

ABSTRACT:

Background

Procollagen-lysine 2-oxoglutarate 5-dioxygenase 1 (PLOD1) is important for extracellular matrix formation and is involved in a variety of diseases, including cancer; however, its role in gastric cancer (GC) remains elusive. Therefore, this study aimed to explore the mechanistic importance of PLOD1 as a regulator of GC.

Methods

We examined the potential function and prognostic efficiency of PLOD1 in GC using a variety of bioinformatics methods. In vitro, we assessed the ability of PLOD1 to regulate GC by CCK-8 assay, Transwell assay, and Elisa assay analysis. Furthermore, we evaluated the effect of PLOD1 on the immune escape of GC cells by CCK-8 assay, flow cytometry, and Elisa assay.

Results

Analysis of PLOD1 expression in gastric cancer and other cancers i

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12586265 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature