Cell-Free and Concentrated Ascites Reinfusion Therapy (CART) Shows Enhanced Efficacy in Gynecological Cancer Patients: A Post-Marketing Surveillance Study.

ABSTRACT:

Introduction

Ascites management is crucial for gynecological cancer patients requiring long-term treatment. Cancer type-specific differences may influence CART outcomes, but comparative data remain limited. This study evaluated CART efficacy in gynecological versus other cancers.

Methods

This subgroup analysis included 125 cancer patients undergoing 296 CART sessions at 22 Japanese centers (2014-2015). Patients were divided into gynecological cancer (Group G, n = 46) and other cancer groups (Group O, n = 79).

Results

Group G had significantly higher concurrent chemotherapy rates (41.2% vs. 12.3%, p < 0.001) and ascitic protein/albumin concentrations. Group G showed significant renal function improvements: decreased serum creatinine (0.7 ± 0.3 to 0.6 ± 0.3 mg/dL, p < 0

SUBMITTER: Tamura N 

PROVIDER: S-EPMC12586275 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature