Fungal-Bacterial Dysbiosis in IBD: Microbial Biomarkers of Disease Activity.

ABSTRACT: Inflammatory bowel disease is associated with complex changes in the intestinal microbiota. While bacterial dysbiosis has been widely studied, the role of fungal communities and their interaction with bacteria remains less explored. This study aims to characterize both bacterial and fungal populations in patients with Crohn's disease and ulcerative colitis, identifying potential microbial biomarkers and inter-kingdom interactions related to disease activity. We analysed paired intestinal tissue and faecal samples from patients with inflammatory bowel disease. Bacterial, fungal and viral composition were assessed by 16S, ITS DNA and shotgun sequencing, respectively. Bioinformatics analyses were done using Qiime2 and R studio platforms. PERMANOVA and ANOSIM analyses revealed significant comp

SUBMITTER: Arribas-Rodriguez E 

PROVIDER: S-EPMC12586356 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature