Clemastine ameliorates cognitive deficits in an experimental rat model of chronic cerebral hypoperfusion.

ABSTRACT: Chronic cerebral hypoperfusion (CCH) profoundly affects patient well-being and has been proposed as a risk factor for cognitive impairment and dementia. However, due to the limited understanding of the pathophysiology of CCH, there are currently no effective preventive or therapeutic approaches for CCH-associated cognitive impairment. Therefore, identifying new targets for CCH is essential to bridge this knowledge gap. In this study, we sought to determine whether enhanced myelination could prevent cognitive impairment associated with CCH. Experimental CCH was induced via bilateral common carotid artery occlusion (BCCAO) in rats, and clemastine, a well-established pro-myelinating agent, was administered to boost myelin renewal. A series of behavioral tests was performed to assess learning

SUBMITTER: Zong X 

PROVIDER: S-EPMC12586381 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature