TGF-beta coordinates changes in Keratin gene expression during complex tissue regeneration.

ABSTRACT: Zebrafish larval tail regeneration can be broadly broken down into three phases: wound repair, initiation of regeneration and redevelopment of the tail. We and others have shown that activation of the Hedgehog and TGF-beta signalling pathways is required to trigger tail regeneration. In this study we initially focus on these two pathways to better understand their role regeneration. We have found that Hedgehog signalling acts upstream of the TGF-beta pathway by activating transcription of the TGF-beta ligand tgfb1a. We have identified differentially expressed genes that are regulated after tail excision as well as those that are dependent upon TGF-beta signalling. From this analysis we found that Keratin genes fall into two categories of co-expression: one set that is upregulated by TGF-be

SUBMITTER: Meshram DD 

PROVIDER: S-EPMC12586446 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature