Portal hypertension contributes to ascites formation via the Piezo1-nuclear factor kappa-B-aquaporin1 pathway in liver cirrhosis.

ABSTRACT: Portal hypertension is critical to the development of ascites in liver cirrhosis. The aim of our study was to evaluate the contribution of portal hypertension to ascites formation and explore the underlying mechanism. Here, the role of portal hypertension in cirrhotic ascites was determined through a meta-analysis of portal pressure in cirrhotic patients and animal models. The mechanism underlying the involvement of portal hypertension in ascites formation was explored. The meta-analysis showed hepatic venous pressure gradient in patients with cirrhosis with ascites was significantly higher than that in patients with cirrhosis without ascites. In carbon tetrachloride (CCl₄)-treated rats, portal pressure of cirrhotic rats with ascites (19.83 cmH₂O) was significantly hi

SUBMITTER: Wei N 

PROVIDER: S-EPMC12586457 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature