The Genetic Architecture of the Human Corpus Callosum and its Subregions.

ABSTRACT: The corpus callosum (CC) is the largest set of white matter fibers connecting the two hemispheres of the brain. In humans, it is essential for coordinating sensorimotor responses and performing associative or executive functions. Identifying which genetic variants underpin CC morphometry can provide molecular insights into the CC's role in mediating cognitive processes. We developed and used an artificial intelligence based tool to extract the midsagittal CC's total and regional area and thickness in two large public datasets. We performed a genome-wide association study (GWAS) meta-analysis of European participants (combined N = 46,685) with generalization to the non-European participants (combined N = 7040). Post-GWAS analyses implicated prenatal intracellular organization and cell growt

SUBMITTER: Bhatt RR 

PROVIDER: S-EPMC12586663 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature