The Hox Gene, <i>abdominal-A</i>, controls the size and timely mitotic entry of neural stem cells during CNS patterning in <i>Drosophila</i>.

ABSTRACT: Cell size is strongly correlated with several biological processes, including the cell cycle and growth. Here, we investigated the regulation of stem cell size during Drosophila central nervous system (CNS) development and its association with cell fate. We note that neural stem cells (NSC) in different regions of the ventral nerve cord increase their size at different rates. Thoracic NSCs grow at a faster rate compared with those in the abdominal region during larval development. We show that in addition to the known role in apoptosis and nervous system remodeling, larval expression of abdA is crucial in regulating the rate of postembryonic NSCs size increase, their timely exit from G₂ phase and mitotic rate. We demonstrate that when abdA expression is lost

SUBMITTER: Das P 

PROVIDER: S-EPMC12586889 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature