Modeling the 2022 mpox outbreak with a mechanistic network model.

ABSTRACT:

Background

The 2022 outbreak of mpox affected more than 80,000 individuals worldwide, most of whom were gay, bisexual, and other men who have sex with men (GBMSM) who likely contracted the disease through close contact during sex. Given the unprecedented number of mpox infections and the new route of infection, there was substantial uncertainty about how best to manage the outbreak.

Methods

We implemented a dynamic agent-based network model to simulate the spread of mpox in a United States-based GBMSM population. This model allowed us to implement data-informed dynamic network evolution to simulate realistic disease spreading and behavioral adaptations.

Results

We found that behavior change, the reduction in one-time partnerships, and widespread vaccination are effect

SUBMITTER: Crenshaw EG 

PROVIDER: S-EPMC12587546 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature