Incidence, Clinical Features, and Prognostic Value of New-Onset Renal Impairment in Multiple Myeloma.

ABSTRACT:

Background

Previous studies mainly focused on renal impairment (RI) at multiple myeloma (MM) diagnosis, with few investigating new-onset RI post-MM diagnosis. This study aims to indicate the incidence, clinical characteristics and predictive value of new-onset RI in MM patients.

Methods

We conducted a multicenter, retrospective cohort study including 1953 newly diagnosed MM patients from West China Hospital from July 1, 2008, to February 30, 2024 and the international MMRF-CoMMpass database. Among them, 1770 patients received novel therapeutic agents including immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs) as first-line therapy. RI was defined as serum creatinine higher than 2 mg/dL or impaired creatinine clearance (< 40 mL/min/1.73m²). The associa

SUBMITTER: Liu X 

PROVIDER: S-EPMC12588725 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature