Combined assessment of inflammation and food intake contributes to prognostic stratification of gastric cancer.

ABSTRACT:

Background

Patients with gastric cancer (GC) present with chronic inflammation and malnutrition risk. Lymphocyte-to-C-reactive protein ratio (LCR) and food intake are promising indicators for predicting inflammatory and nutritional states.

Methods

This multi-center cohort study included 763 patients with GC. Time-dependent receiver operating characteristic curves were generated to determine the prediction accuracy of 16 systemic inflammatory indicators. Association of the model constructed by LCR and food intake with overall survival (OS) were analyzed using the Kaplan-Meier method and Cox regression model.

Results

In this analysis, patients with reduced food intake accounted for 60.4%. The area under the curve and C-index of LCR for all-cause mortality were higher th

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12588835 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature