Preserved ictal responsiveness in right mesial temporal lobe epilepsy: metabolic correlates in posterior temporal networks with FDG-PET.

ABSTRACT:

Objective

Automatisms with preserved responsiveness (APR) represent a distinctive clinical feature in right mesial temporal lobe epilepsy (MTLE). This study aimed to investigate whether interictal FDG-PET hypometabolism correlates with impaired responsiveness during seizures.

Methods

We retrospectively analyzed 49 patients with right MTLE who underwent presurgical evaluation. Patients were stratified into APR+ (n = 16) and APR- (n = 33) groups based on a standardized four-domain assessment (orientation, memory, verbal command, motor execution). Interictal FDG-PET hypometabolism was visually scored on a three-point scale (0 = absent, 1 = moderate, 2 = severe) across 31 predefined brain regions by three blinded epileptologists. Group comparisons were performed us

SUBMITTER: Choo YS 

PROVIDER: S-EPMC12588851 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature