Food responsiveness, addiction, and hyperphagia in Prader-Willi syndrome: a cross-sectional study of 210 Chinese patients.

ABSTRACT:

Objective

Prader-Willi syndrome (PWS) is the most common genetic syndromic obesity, characterized primarily by hyperphagia. It was described as excessive appetite, defective satiety, and obsession with food. However, the underlying mechanisms of hyperphagia in PWS remain obscure. This study aimed to determine the eating behavior patterns and food addiction tendencies in patients with PWS.

Methods

210 patients with PWS from 26 provinces in China were enrolled in this study. The translated Children's Eating Behavior Questionnaire and modified Yale Food Addiction Scale for Children 2.0 were adopted for evaluation.

Results

This study revealed that (i) In patients with PWS, the eating behavior patterns are abnormal and the risk of food addiction is high. (ii) Patients with

SUBMITTER: Hu CX 

PROVIDER: S-EPMC12588852 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature