Case Report: A case series of Lhermitte-Duclos disease with surgical intervention.

ABSTRACT:

Background

Lhermitte-Duclos disease (LDD) is a rare dysplastic cerebellar gangliocytoma often associated with Cowden syndrome and phosphatase and tensin homolog (PTEN) alterations. We report a three-case series focusing on imaging, histopathology, PTEN testing, surgical decision-making, and outcomes.

Method

We retrospectively identified three adults with LDD who underwent standardized preoperative imaging [including magnetic resonance spectroscopy (MRS) and perfusion when feasible], surgery, and structured follow-up with Karnofsky Performance Status (KPS). PTEN assessment included immunohistochemistry and/or genetic testing where available.

Results

All patients in this case series were women (18-53 years). Two underwent subtotal resection and one underwent gross total

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12588853 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature