Optimizing Xenon 129 Ventilation MRI in Cystic Fibrosis with Spiral Imaging and Flip-Angle Correction.

ABSTRACT: Purpose To implement and evaluate two-dimensional spiral hyperpolarized xenon 129 (¹²⁹Xe) ventilation MRI with flip-angle (FA) correction, as compared with conventional N4ITK (N4) correction, in healthy individuals and those with cystic fibrosis (CF). Materials and Methods In this prospective study, participants with mild CF and age-matched healthy control participants underwent ¹²⁹Xe ventilation MRI using both rapid spiral (approximately 3 seconds) and conventional Cartesian (approximately 10 seconds) acquisitions. Images were corrected using N4 bias correction, and ventilation defect percentage (VDP) was calculated using median-anchored generalized linear binning (mGLB). Separately, B₁ inhomogeneities in spiral images were FA-corrected and analyzed using

SUBMITTER: Hussain R 

PROVIDER: S-EPMC12588888 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature