Vitamin D levels in early and middle pregnancy and preeclampsia: a systematic review and meta-analysis.

ABSTRACT:

Background and aims

Previous studies have indicated a potential association between low vitamin D levels in early pregnancy and an increased risk of hypertensive disorders, including preeclampsia. Given the substantial maternal and fetal morbidity associated with preeclampsia, identifying preventive strategies is crucial. This meta-analysis aimed to evaluate the relationship between vitamin D status in early and middle pregnancy and the development of preeclampsia.

Methods

A comprehensive literature search of PubMed, Scopus, Web of Science, and Cochrane Library databases was conducted up to June 23, 2023, to identify relevant observational studies. Included studies were assessed for methodological quality, and data on maternal vitamin D concentration and the risk of preeclam

SUBMITTER: Zakerinasab F 

PROVIDER: S-EPMC12588914 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature