Immunomodulatory Effects of Multi-Strain Probiotic Capsules for Psoriatic Arthritis: A Pilot Double-Blind Randomized Controlled Trial.

ABSTRACT: Psoriatic arthritis (PsA) is characterized by joint inflammation and is frequently associated with psoriasis. Gut dysbiosis has been implicated in PsA pathogenesis, raising interest in probiotics as potential immunomodulatory agents. In a pilot, double-blind, randomized, placebo-controlled trial, 14 adults aged 18-60 years with mild-to-moderate psoriatic arthritis (PsA; Disease Activity in Psoriatic Arthritis [DAPSA] < 28) were randomized to receive either probiotic capsules or placebo daily for 12 weeks. The probiotic group received a multi-strain cocktail with a total concentration of 1 × 10⁹ CFU (including Lactobacillus rhamnosus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus helveticus, Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus bulgar

SUBMITTER: Alshihmani AHH 

PROVIDER: S-EPMC12588955 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature