Effects of Shexiang Baoxin pill combined with exercise rehabilitation training on long-term prognosis of CTO-PCI patients: study protocol for randomized controlled trial.

ABSTRACT:

Background

CTO-PCI is generally successful, but 40-55% of patients experience coronary microvascular dysfunction (CMVD) afterward, raising the risk of cardiovascular issues. Shexiang Baoxin Pill (SBP) aids angiogenesis and cardiovascular health, while exercise rehabilitation boosts coronary collateral circulation. However, the combined impact of these treatments on CTO-PCI patients remains under-researched.

Methods

This prospective, single-center, randomized controlled trial involves CTO-PCI patients divided into four groups: Shexiang Baoxin pill, exercise rehabilitation, combined, and control. The exercise protocol includes pre-assessment, a three-phase prescription, CPET-based intensity grading, various exercise methods, remote monitoring, and quality control. The primary

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12588978 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature