The synergy between life's essential 8 and muscle strength on cardiovascular disease risk.

ABSTRACT:

Background

While muscle strength is a known CVD risk factor in aging, its influence across the spectrum of Life's Essential 8 (LE8) scores - the American Heart Association's (AHA's) comprehensive metric of cardiovascular health that includes diet, physical activity, sleep, nicotine exposure, body mass index, blood lipids, blood glucose, and blood pressure - remains unclear.

Methods

We analyzed data from 237,682 individuals (mean age 55.64 ± 8.06 years) from UK Biobank. Muscle strength was assessed by grip strength and categorized into high, medium, and low based on tertiles. LE8 was classified into ideal (≥80), medium (50-79), and low (<50) based on AHA guideline. We used the Cox regression to examine the joint association of muscle strength and LE8 with incident CVD, includ

SUBMITTER: Li L 

PROVIDER: S-EPMC12589015 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature