Disrupted macrophage autophagy as a driver of cell death and LPS-induced lethal shock in systemic inflammation.

ABSTRACT: Systemic inflammatory response syndrome (SIRS) can be primed by infectious or non-infectious stimuli and may progress to life-threatening organ failure. An altered balance between pro- and anti-inflammatory response is commonly observed in SIRS, yet the core molecular events driving severe SIRS remain poorly defined. Moreover, the roles of macrophages and autophagy in SIRS have been pointed out. Here a high susceptibility to LPS-induced lethal shock in mice deficient in autophagy in myeloid cells (Atg5^f/fLysM-cre⁺ ) following a single dose of 0.5 mg/kg (60% mortality vs. 0% in wild type after 24h) was observed. Using a very low dose of LPS (0.1 mg/kg), Atg5^f/fLysM-cre⁺ mice showed rapid tissue injury, notably in the liver and spleen

SUBMITTER: Chekroune T 

PROVIDER: S-EPMC12589025 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature