Electroanatomy of hippocampal activity patterns: theta, gamma waves, sharp wave-ripples, and dentate spikes.

ABSTRACT: Monitoring representative fractions of neurons from multiple brain circuits in behaving animals is necessary for understanding how different brain regions interact. Using multishank, high-density recording silicon probes (up to 1,024 sites), we describe the main characteristic LFP patterns in the hippocampus, including sharp wave-ripples (SPW-Rs), dentate spikes (DSs), theta, and gamma oscillations. Our novel observations primarily relate to the distinction between subclasses of SPW-Rs and DSs, as well as their neuronal spiking correlations. In addition to the classical SPW-Rs, initiated in the CA2-3 recurrent collateral system and characterized by a large negative sharp wave (sink) in the mid-CA1 stratum radiatum (SPW-R^Rad), a small subset of ripples, associated with a sink in

SUBMITTER: Paleologos N 

PROVIDER: S-EPMC12589087 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature