Sublethal concentrations of antibiotics enhance transmission of antibiotic resistance genes in environmental <i>Escherichia coli</i>.

ABSTRACT: Third-generation cephalosporin-resistant Enterobacterales are ranked second on the World Health Organisation (WHO)'s Bacterial Priority Pathogens List. Amongst them, extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) are used by the WHO as sentinel organisms to monitor the spread of antibiotic resistance worldwide and are often associated with mobilisable multidrug resistance (MDR). However, we know less about how ESBL-producing genes spread in environmental E. coli. This study investigates how the bla _CTX-M-15 gene from ESBL-Ec isolated on a UK dairy farm could transfer between strains. For this study, 39 E. coli were isolated from a single dairy farm over 4 months, using cefotaxime-supplemented selective media. All had similar antibi

SUBMITTER: Gray-Hammerton CJ 

PROVIDER: S-EPMC12589106 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature