Continuous cell-type diversification in mouse visual cortex development.

ABSTRACT: The mammalian cortex is composed of a highly diverse set of cell types and develops through a series of temporally regulated events^1-3. Single-cell transcriptomics enables a systematic study of cell types across the entire timeline of cortical development. Here we present a comprehensive and high-resolution transcriptomic and epigenomic cell-type atlas of the developing mouse visual cortex. The atlas is built from a single-cell RNA sequencing dataset of 568,654 high-quality single-cell transcriptomes and a single-nucleus Multiome dataset of 200,061 high-quality nuclei, which were densely sampled across the embryonic and postnatal developmental stages (from embryonic day 11.5 to postnatal day 56). We computationally reconstructed a transcriptomic developmental trajectory map of a

SUBMITTER: Gao Y 

PROVIDER: S-EPMC12589121 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature