Repeated head trauma causes neuron loss and inflammation in young athletes.

ABSTRACT: Repetitive head impacts (RHIs) sustained from contact sports are the largest risk factor for chronic traumatic encephalopathy (CTE)^1-4. Currently, CTE can only be diagnosed after death and the events that trigger initial hyperphosphorylated tau (p-tau) deposition remain unclear². Furthermore, the symptoms endorsed by young individuals are not fully explained by the extent of p-tau deposition², severely hampering therapeutic interventions. Here we observed a multicellular response prior to the onset of CTE p-tau pathology that correlates with number of years of RHI exposure in young people (less than 51 years of age) with RHI exposure, the majority of whom played American football. Leveraging single-nucleus RNA sequencing of tissue from 8 control individuals

SUBMITTER: Butler MLMD 

PROVIDER: S-EPMC12589125 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature