Molecular and cellular dynamics of the developing human neocortex.

ABSTRACT: The development of the human neocortex is highly dynamic, involving complex cellular trajectories controlled by gene regulation¹. Here we collected paired single-nucleus chromatin accessibility and transcriptome data from 38 human neocortical samples encompassing both the prefrontal cortex and the primary visual cortex. These samples span five main developmental stages, ranging from the first trimester to adolescence. In parallel, we performed spatial transcriptomic analysis on a subset of the samples to illustrate spatial organization and intercellular communication. This atlas enables us to catalogue cell-type-specific, age-specific and area-specific gene regulatory networks underlying neural differentiation. Moreover, combining single-cell profiling, progenitor purification a

SUBMITTER: Wang L 

PROVIDER: S-EPMC12589127 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature