Chromatin accessibility during human first-trimester neurodevelopment.

ABSTRACT: The human brain develops through a tightly organized cascade of patterning events, induced by transcription factor expression and changes in chromatin accessibility. Although gene expression across the developing brain has been described at single-cell resolution¹, similar atlases of chromatin accessibility have been primarily focused on the forebrain^2-4. Here we describe chromatin accessibility and paired gene expression across the entire developing human brain during the first trimester (6-13 weeks after conception). We defined 135 clusters and used multiomic measurements to link candidate cis-regulatory elements to gene expression. The number of accessible regions increased both with age and along neuronal differentiation. Using a convolutional neural network, we i

SUBMITTER: Mannens CCA 

PROVIDER: S-EPMC12589128 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature