Transcriptomic and spatial organization of telencephalic GABAergic neurons.

ABSTRACT: The telencephalon of the mammalian brain contains multiple regions and circuits that have adaptive and integrative roles in a variety of brain functions. GABAergic neurons in the telencephalon are diverse; they have many circuit functions, and dysfunction of these neurons has been implicated in various brain disorders^1-3. Here we conducted a systematic and in-depth analysis of the transcriptomic and spatial organization of GABAergic neuronal types in all regions of the mouse telencephalon and their developmental origins. This was accomplished using 611,423 young adult single-cell transcriptomes and 614,569 single-cell transcriptomes collected from multiple prenatal and postnatal developmental timepoints. We present a hierarchically organized adult telencephalic GABAergic neurona

SUBMITTER: van Velthoven CTJ 

PROVIDER: S-EPMC12589142 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature