Management and Outcomes in Patients with Breast Cancer with 1-of-1 and 2-of-2 Positive Sentinel Nodes.

ABSTRACT:

Background

The ACOSOG-Z0011 and AMAROS trials showed that axillary lymph node dissection (ALND) provided no benefit for patients with 1-2 positive sentinel lymph nodes (+SLNs). There remains apprehension to omit ALND for patients in whom only 1-2 SLNs are retrieved and all are positive. This study evaluates current practices and pathological findings when ALND is pursued.

Patients and methods

We identified female patients with cT1-3N0 breast cancer who underwent sentinel lymphadenectomy from 2018 to 2021 in the National Cancer Database (NCDB). Patients with ≤ 2 SLNs were included and categorized on the basis of the number positive/removed: 0/1, 1/1, 1/2, and 2/2. We assessed the rates and factors associated with ALND.

Results

A total of 102,802 patients were included:

SUBMITTER: Lyons W 

PROVIDER: S-EPMC12589349 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature