Clinicopathologic Characteristics and Clinical Outcomes of Patients with Testicular Mesothelioma.

ABSTRACT:

Background

Mesothelioma of the tunica vaginalis testes (testicular mesothelioma [TM]) is a rare tumor, comprising less than 5% of mesotheliomas. Surgical intervention is the current standard of care, whereas the role of systemic therapies remains undefined.

Methods

We retrospectively reviewed 36 patients with pathologically confirmed TM treated at Memorial Sloan Kettering Cancer Center (MSK) between January 1996 to May 2023. Clinicopathologic data, treatments received, and clinical outcomes were reported. Surgical pathology samples, when available, underwent next-generation sequencing (NGS) using MSK-IMPACT. Overall survival (OS) was calculated by using the Kaplan-Meier method.

Results

Median age at diagnosis was 64 years (range 24-93). Histologically, 22 (61%) tumors

SUBMITTER: Agrawal P 

PROVIDER: S-EPMC12589385 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature